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The Student Center bustles as the vibrant social and academic heart of the campus. (Photo by Steve Zylius / UC Irvine) |
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| Stealth tactic makes chemotherapy smarter |
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From left: the study’s corresponding author, Darci Trader, associate professor of pharmaceutical sciences, and co-author Claudia Benavente, associate professor of pharmaceutical sciences. |
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Chemotherapy faces a fundamental problem: The same drugs powerful enough to kill cancer cells can also damage healthy tissue. UC Irvine researchers are changing that equation with an experimental prodrug that delivers its toxic, cancer-killing payload inside cells with high immunoproteasome activity, which occurs with certain cancers. Healthy cells are largely unaffected by the masked drug, which is inactive until it enters a cancer cell. “Our goal is to take advantage of something cancer cells are already doing differently and use that difference to activate a drug where we want it to be toxic,” said Darci Trader, associate professor of pharmaceutical sciences and vice chair of postgraduate studies in that department. “Rather than relying on traditional development of enzyme inhibitors, we’re harnessing the unique immunoproteasome activity as a prodrug trigger.” |
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On a campus known for scientific discovery and research, a different kind of impact is taking place through the proud musical tradition of mariachi. At UC Irvine, the distinctive Mexican sound is embodied by Mariachi Orgullo de UCI, the university’s first ensemble of its kind. Founded in April 2024 by Brendaitzel Torres, the student-led organization began with a simple idea: create a space where people could connect with Mexican culture through music. What started with a flyer and a QR code has grown into a 15-member group performing throughout UC Irvine, Orange County and neighboring communities. |
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| UCI Health hosts Royal Philharmonic Orchestra |
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What happens when medicine and music come together to aid stroke recovery? Experts from across UC Irvine recently joined musicians from London’s Royal Philharmonic Orchestra for specialized training ahead of a new stroke rehabilitation program at UCI Health. The collaboration brought together geriatricians, stroke specialists, School of Medicine students and faculty and student musicians from the Claire Trevor School of the Arts to learn how creative group music-making can support patients during recovery. It’s an interdisciplinary approach to an incredibly human goal: helping people reconnect, rebuild and recover after a stroke. |
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| | zotALERT emergency text notifications |
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UC Irvine is updating zotALERT to make it easier for faculty, staff and students to receive emergency text notifications for urgent life-safety information during campus emergencies, including evacuations, shelter-in-place situations and active threats. Starting Oct. 13, you will be automatically enrolled in zotALERT emergency text notifications using the mobile number currently on file with UC Irvine. For more information, including answers to frequently asked questions, visit the zotALERT webpage. |
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| | Celebrating the UC to DC connection |
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UCDC students in front of the White House with recently retired faculty member Marc Sandalow, a journalist who spent 18 years teaching in the program. |
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For 25 years, the UC Washington Center has been providing students a fast track to the heart of Washington, D.C. Hundreds of students each year spend a term not just learning in classrooms but also as interns in the program – building community and making connections across Capitol Hill and Washington, D.C. The impact of the program is lasting – many alumni now work in government and policy, including through careers in Congress, federal agencies, national organizations and journalism. |
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| | Running toward a new legacy |
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Cynthia Herrera is blazing her own trail. As a first-generation college student, a dedicated public health scholar and a two-time Big West Champion with the UC Irvine women’s track & field team, she is proof that all her family’s hard work and sacrifice were worth it. Herrera was born and raised in Santa Clarita after her parents moved to the U.S. from Puebla, Mexico, about 30 years ago to give their children a better life. Now a junior, Herrera is doing more than taking advantage of those opportunities; she is rewriting what is possible. “My parents just wanted to give me and my brothers better opportunities than they had,” Herrera said. |
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| #UCIconnected spotlights interesting updates from the UC Irvine community. #IamUCI spotlights profiles of students, faculty, staff and alumni. Send submissions via email or post on social media with the #UCIconnected or #IamUCI hashtags. |
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Forbes, Oct. 3 Cited: Jill Johnston, associate professor of environmental & occupational health |
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PBS Newshour, Oct. 2 Cited: Danielle Thomsen, professor of political science |
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The Atlantic, Oct. 1 Cited: Charis Kubrin, professor of criminology, law and society |
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